Depends what type of cursors you want to create. Do yiou want to create standard windows cursors in for format of .cur and .ani. (.cur are static cursors, .ani is animated cursors) Note that the windows cursors are limited to 32x32 pixels. I think a program called Microangelo can make there, though I'm nt sure it's free or not.
Then you could create CursorXP cursors that doesn't have these limitations.