I've also found with dual monitors that not only run different resolutions, but also different scaling on each monitor on Windows 10, when moving windows between screens, it messes up the explorer.  Disk usage bars extend to far end of windows.  Overall explorer window resizes without my telling it too.  And I don't mean the auto scaling way.  I mean I have it on one screen.  Move it to other screen and window resizes as expected (as per scaling).  Window layout messes up.  Move window back to other screen, scaling kicks in again as expected, but overall window is now much bigger forcing me to resize the window again.

It only seems to happen with regular windows 10.  Using Display Fusion, there is no scrolling effect, although the second screens task bar is warped and the start button is crappy looking. but that may be a DF problem.