There is some incompatibility with windowblinds and GTK. I'm not sure which side causes the error (gtk or WB), so I'll post it here for information anyways.. (and sorry if this is already documented.)
Basically, if any change in settings is applied in windowblinds, GTK applications (OpenOffice, Inkscape, Gaim etc..) will often lock up. Sometimes the lockup stops after a few minutes, sometimes it's permanant and the programs need to be closed via the task manager.
The bug is present both in WB4 and 5. Never tried it on earlier versions. Workaround is just to not apply anything with such applications running, but it's annoying when you accidentally apply something.