I've also used Trillian since it's early beta versions and have found it one of the most useful tools I've had.
I used to game a lot (Counter-Strike, Day of Defeat, BF 1942, etc) and found that I needed to communicate with friends on almost every other IM, so I relished having Trillian since I didn't have to run separate programs.
Now-a-days I don't game much and I really only use MSN (and e-messenger.net at work) and Skype but I still have contacts on the other networks so I still keep Trillian around. I wonder if they'll integrate Skype into it...?