I use it constantly, except when I'm installing something. I'm really busy and I had similar time issues with customizing new themes--what I ended up doing is using ObjectDock+ for most of my links, and using DX to change to look of the desktop and ad useful objects/widgets. Even then, I usually keep pretty much the same look (I seem to completely change every couple of weeks) and just adjust some colors and, of course, the wallpaper. I use all of the Object Desktop components to increase productivity (looking nice is a plus), and DesktopX is particularly useful because I can just make an object real quick to do whatever I need done. I'm a PhD student, and I often end up making objects to search various databases, etc. I also have one that tells me when my library books are done or there is something in the library that I need to pick up (it just checks my account at the library twice a day). I also have an object that checks my department web calendar several times a day and throws up a message if there is something to watch for. I always have a clock (taskbar hidden), I use Rainlendar (I'm waiting for a seemless way to plug DX calendars into Outlook, but don't have time myself), and I track the weather on Object Dock. I also have a cluster of guages that I bring up when needed, and have a really stripped down media player on my desktop at all times. When I don't have dual monitors running, I also like to use the multiple desktops feature.
I guess that's a really long way of saying, "yeah, I use it all the time". In fact, I couldn't imagine living without Windowblinds (transparency and roll-up are huge productivity boosters), ObjectDock Plus (a great way to organize everything I need to get to, email checker, weather, and the magic 8 ball Q: "should I give this student a C-", A: "without a doubt"), RightClick (because that's just what should happen when you right-click), and Cursor XP (I can actually see my cursor at high resolutions, without it looking horrible). Plus, having a nice environment to look at seems to really boost my productivity.