If the target audience is fellow graphic designers using IE then it works.
I personnally don't like orange (teracotta) and white, but that's because it's the colours used for where I work and it looks tired and old to me because of that...I'm sure to other people those colours conjour up fresh oranges, and good things like that
The layout actually works fine. The menu is obvious despite it's possition, the roll-overs work well and the graphics fit the style. The navigation works fine - obvious and clear. Overall, it's good.