Here's an issue I haven't yet fully been able to reproduce. But it seems to happen either after a reboot or after restarting explorer.exe:
I'm currently using the default "Cairo Dark" theme without having made any customizations to it. Active icons on my taskbar are blue and so is the accent color. Here's how it looks in Curtains and on my system as well:

But after a reboot or restarting explorer.exe, the theme seems to change its colors on its own: The accent color on my Start menu changes from Blue to Orange and Taskbar icons have a red background. I'm not really sure what is causing this issue, but since it happened multiple times now, I wanted to let you know.
I'm running Windows 10 Version 2004 (Build 19041.388, 64-bit) and Groupy is the only other Theming/Modding Software I am using on my System. I already did a purge and reinstall of Curtains, but without any luck. I haven't tried a different theme yet because I'm quite fond of Cairo Dark.
Any help is much appreciated!