I've been running start10 v1.11 on windows 10 pro (1511 build).
I have 2 UHD monitors (each with resolution of 3840x2160), and the display is set to scale text by 125% (not sure if that's relevant).
I also have windows configured to show the taskbar on all displays.
On the left (main) monitor when I click the start button, the menu appears in the bottom left corner, as expected.
If I click the start button on the right monitor the menu appears at the left, but not necessarily at the bottom. It appears to get a random Y co-ordinate. This only happens the first time I click on the right start button. On subsequent clicks it is correctly at bottom left, and it stays OK until next boot.
This is a very minor issue, but I thought I'd let you know !
I've just upgraded to the Win10 Anniversary Edition (build 1607) and this problem is still there (I didn't expect to go away, but again this is just for your info).
I'm not sure if this issue occurs on all multi monitor configurations, or just on specific resolutions.