Most mouse based actions in windows take place towards the right edge of the screen. Here's how:
1. Scrolling browser or app windows
2. Minimize, close or restore actions
3. Systray actions
Application menus are placed on the top left, while taskbars are the left bottom.
Would it not make sense to rationalize this positioning. We could move most fucntionality to the right bottom. This will you would have to move your mouse a lot less.
There is no science to this yet. Just an idea