I think the 2nd expansion for Elemental would be a good test case for 64-bit and how it goes.
Reasoning:
a good number of folks would be getting the game for free, provided Stardock keeps its promise in that regard (the pre-order folks). Trying something experimental would make sense, provided FE ends up being what it has the potential of being.
I assume that after that 2nd game, it's on to GalCiv III in 2015 or so, if 64-bit FE expansion does well, then making GCIII 64-bit would be a no-brainer.
How many folks purchase TBS games, and don't have a 64-bit capable machine? That's the real question. I suspect it's a very low number- maybe around 5% at most.