the_great_deceiver (and Stardock): I think the majority of us would rather Stardock fixed Desktop Collage first to handle randomizing, or multiple photo directories. But yes, I run two monitors, and they always get the aspect ratio wrong on the second display. Would be nice if they'd make it handle the whole thing. Would be *REALLY* nice if someday, they'd open-source something like that.

Everyone with more than one video card: The problem with multiple video cards is the bus. If you take two monitors, plug each one into a different video card, your performance will drop. As soon as you turn off one of those cards, it's no longer eating up bandwidth. Most video cards support two monitors on one board, so for the majority, they don't need the dual cards (not including SLI or CrossFire). It's possible that if Stardock can make only the primary card run an animated desktop, the usage will go down, but it will not go down to the level of one card. That other card is still talking on the bus, and still using up bandwidth.
Ultramon/Multimon: These use a hack to put different wallpaper on multiple monitors. They take the BMPs you choose, and the resolutions, and create a new BMP of the full size, and tell windows not to scale it. For instance, a 1600x1200 and a 1280x1024 display, side by side. It will create a BMP file of 2880x1200, and paste in both BMPs, with a small region on the lower-right that's blank. Put this up on your desktop, and it neatly fills both.