I'm forever cleaning and tweaking things....constantly changing skins and saving new desktops as suites in ThemnManager. I too use TweakUI and X-Setup, but I also have a proggie called Fresh-UI put out by a company called Fresh Devices
WWW LinkIt's similar to TweakUI but it has a few more settings to play with....they also put out FreshDiagnose and FreshDownload, both are handy tools for benchmarking and downloading respectively. They are free to use but they do ask that you register them, which is also free to do.