Thanks, Sir Bichur. I've discovered that this is a problem with WindowFX 3.0 beta. When WinFX is running, I can't open saved MS Office Excel Workbook files, only the Excel application. If I unload WinFX, the problem goes away. I posted this issue in the support discussion for WinFX, but I messed things up with a multiple post and accidentally deleted all of them! I know, I'm an idiot. Sad thing is, there were 2 replies to my original post, and all I was able to read from the first reply was that someone had confirmed it. That's all I know! Hopefully, someone at Stardock support knows about the issue now.